Jackson State University

Chemistry Seminar Series

Md. Alamgir Hossain
Assistant Professor of Chemistry

MSc. (1990), Dhaka University, Bangladesh

PhD (1996),Hokkaido University, Japan

Alexander von Humboldt Fellow (1997-1998), Germany

Assistant Professor (1998-2000), Dhaka University, Bangladesh

Postdoctoral Fellow (2000-2005), University of Kansas

Research Interest

Model Receptor for Peptide: A strategy for binding of both C and N terminal of unprotected peptide has been developed by introducing of peralkylammonium ion and crown ether. Incorporation of a dansyl group provides further complementarity to side chain of peptide. The model as shown in Figure is the first synthetic ditopic receptor which binds natural tripeptides in water.

Peptide receptor	Sulfate sandwich
J. Am. Chem. Soc. 1998, 11208	Highlighted in Chemical and Engineering News

Rcecptors for Biological and Environmental Relevant Anions: Anions play an important role in both biology and chemistry. It is known that more than 70% of enzymetic reactions in human body are involved with anions. Anions are also very important in medicine, and catalysis. In environment excess anions e. g. nitrate and phosphate resulted from the use of fertilizer, pollutant anions like sulfate, pertechnetate from nuclear waste, arsenate and fluoride from ground water are of concern. Therefore the design and synthesis of suitable receptors for anions is very important in both understanding the biochemical interaction and   in separation and removal process of such inorganic pollutant. Our research aims at the synthesis of target receptors e.g. quaternary macrotricyclic peralkyl-ammonium ions, polyamine macrocycles and cryptands. Recently we focus on neutral amide and thioamide based receptors for separation and removal of anions.

	Vol. 44, Issue 07 April 4, 2005 Cover Anion/water inclusion complexes in a hexaprotonated azacryptand ligand showing two encapsulated fluorides linked through a cascading water (top) and ditopic bromide/water and chloride/water complexes (bottom). The famous Niagara Falls cascade forms the background. Picture courtesy of Meng-Yin Yang, University of Buffalo. See M. A. Hossain, P. Morehouse, D. Powell, and K. Bowman-James, p 2143.
The First Synthetic Anion cascade	Click for the Article
Angew. Chem. Int. Ed., 2002, 41, 2335

Binding Studies: High field NMR, UV and fluorescent spectroscopies are used for the analyses of binding contributions and conformations of supramolecular complexes in solution. Binding interaction is quantitatively determined by non-linear regression analysis of titration data.

Catalysis: Thioamide based palladacyles with SCS pincers are being used for the synthesis of Heck and Suzuki type reactions.

Contact Information:

Department of Chemistry

Jackson State University

1325 J. R. Lynch Street

Jackson, MS 39217

Tel: 601-979-3478

Fax: 601-979-3674

Email:alamgir@chem.jsums.edu

Last update: September 7, 2006 (by Alamgir Hossain)